Common genetic polymorphisms in pre-microRNAs and risk of bladder cancer.

ABSTRACT:

Background

At present, inconsistent association between single nucleotide polymorphism (SNP) in pre-miRNAs (hsa-mir-196a2 rs11614913 C/T, hsa-mir-499 rs3746444 A/G, and hsa-mir-146a rs2910164 C/G) and bladder cancer were obtained in limited studies. We performed a case-control study to test whether these three common polymorphisms are associated with bladder cancer. One hundred fifty-nine patients affected by bladder cancer and 298 unrelated healthy subjects were enrolled in the study.

Methods

Using polymerase chain reaction-restriction fragment length polymorphism assay (PCR-RFLP), genotypes of these three SNPs were determined, and their associations with bladder cancer, as well as with clinic pathological factors, and tumor progression were analyzed.

Results

No asso

SUBMITTER: Deng S 

PROVIDER: S-EPMC4603775 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature