Motor network efficiency and disability in multiple sclerosis.

ABSTRACT:

Objective

To develop a composite MRI-based measure of motor network integrity, and determine if it explains disability better than conventional MRI measures in patients with multiple sclerosis (MS).

Methods

Tract density imaging and constrained spherical deconvolution tractography were used to identify motor network connections in 22 controls. Fractional anisotropy (FA), magnetization transfer ratio (MTR), and normalized volume were computed in each tract in 71 people with relapse onset MS. Principal component analysis was used to distill the FA, MTR, and tract volume data into a single metric for each tract, which in turn was used to compute a composite measure of motor network efficiency (composite NE) using graph theory. Associations were investigated between the Expanded

SUBMITTER: Pardini M 

PROVIDER: S-EPMC4603887 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature