Brain arterial remodeling contribution to nonembolic brain infarcts in patients with HIV.

ABSTRACT:

Background

Cerebrovascular disease is a cause of morbidity in HIV-infected populations. The relationship among HIV infection, brain arterial remodeling, and stroke is unclear.

Methods

Large brain arteries (n = 1,878 segments) from 284 brain donors with and without HIV were analyzed to obtain media and wall thickness and lumen-to-wall ratio, and to determine the presence of atherosclerosis and dolichoectasia (arterial remodeling extremes). Neuropathologic assessment was used to characterize brain infarcts. Multilevel models were used to assess for associations between arterial characteristics and HIV. Associations between arterial characteristics and brain infarcts were examined in HIV+ individuals only.

Results

Adjusting for vascular risk factors, HIV infection was as

SUBMITTER: Gutierrez J 

PROVIDER: S-EPMC4603890 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature