Antiproliferative activity of marine stingray Dasyatis sephen venom on human cervical carcinoma cell line.

ABSTRACT:

Background

Venoms comprise mixtures of numerous bioactive compounds that have a wide range of pharmacologic actions. Toxins from venomous animals have attracted the attention of researchers because of their affinity for primary sites responsible for lethality and their efficacy at extremely low concentrations. The venoms of marine stingrays have not been extensively studied and limited data is available on them. The present study aims to evaluate the antiproliferative and biochemical properties of the venom obtained from a species of marine stingray (Dasyatis sephen) on human cervical cancer cell line HeLa.

Methods

The antiproliferative effect of D. sephen venom was determined by MTT assay, and the oxidative stress was determined by lipid peroxidation method along with asses

SUBMITTER: Rajeshkumar RK 

PROVIDER: S-EPMC4603964 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature