Midgut proteome of an argasid tick, Ornithodoros erraticus: a comparison between unfed and engorged females.

ABSTRACT:

Background

The argasid tick Ornithodoros erraticus is the vector of African swine fever virus and of several Borrelia species that cause human relapsing fever in the Iberian Peninsula. The tick midgut is part of the ectoparasite-host interface and expresses proteins that are vital for the survival of the tick. Midgut proteins are therefore potential targets for drug and/or vaccine design aimed at the development of new strategies for tick control. Thus, the aim of this work was the characterization of the proteome of the O. erraticus midgut before and after a blood meal trying to elucidate the induced changes upon blood feeding.

Methods

Midgut tissues from unfed and engorged O. erraticus females were dissected and proteins were fractionated by centrifugation and SDS-PAGE, an

SUBMITTER: Oleaga A 

PROVIDER: S-EPMC4603979 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature