Integrated ordination of miRNA and mRNA expression profiles.

ABSTRACT:

Background

Several studies have investigated miRNA and mRNA co-expression to identify regulatory networks at the transcriptional level. A typical finding of these studies is the presence of both negative and positive miRNA-mRNA correlations. Negative correlations are consistent with the expected, faster degradation of target mRNAs, whereas positive correlations denote the existence of feed-forward regulations mediated by transcription factors. Both mechanisms have been characterized at the molecular level, although comprehensive methods to represent miRNA-mRNA correlations are lacking. At present, genome-wide studies are able to assess the expression of more than 1000 mature miRNAs and more than 35,000 well-characterized human genes. Even if studies are generally restricted to a sm

SUBMITTER: Diaz G 

PROVIDER: S-EPMC4603994 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature