Analysis of liquid bead microarray antibody assay data for epidemiologic studies of pathogen-cancer associations.

ABSTRACT:

Background

Liquid bead microarray antibody (LBMA) assays are used to assess pathogen-cancer associations. However, studies analyze LBMA data differently, limiting comparability.

Methods

We generated 10,000 Monte Carlo-type simulations of log-normal antibody distributions (exposure) with 200 cases and 200 controls (outcome). We estimated type I error rates, statistical power, and bias associated with t-tests, logistic regression with a linear exposure and with the exposure dichotomized at 200 units, 400 units, the mean among controls plus two standard deviations, and the value corresponding to the optimal sensitivity and specificity. We also applied these models, and data visualizations (kernel density plots, receiver operating characteristic (ROC) curves, predicted probabili

SUBMITTER: Colombara DV 

PROVIDER: S-EPMC4604026 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature