Formulation to target delivery to the ciliary body and choroid via the suprachoroidal space of the eye using microneedles.

ABSTRACT: In this work, we tested the hypothesis that particles injected into the suprachoroidal space can be localized at the site of injection or broadly distributed throughout the suprachoroidal space by controlling polymeric formulation properties. Single hollow microneedles were inserted into the sclera of New Zealand White rabbits and injected non-biodegradable fluorescently tagged nanoparticles and microparticles suspended in polymeric formulations into the suprachoroidal space of the eye. When formulated in saline, the particles were distributed over 29-42% of the suprachoroidal space immediately after injection. To spread particles over larger areas of the choroidal surface, addition of hyaluronic acid to make moderately non-Newtonian solutions increased particle spread to up to 100% of the

SUBMITTER: Kim YC 

PROVIDER: S-EPMC4604027 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature