The Effect of Statins on Blood Gene Expression in COPD.

ABSTRACT:

Background

COPD is currently the fourth leading cause of death worldwide. Statins are lipid lowering agents with documented cardiovascular benefits. Observational studies have shown that statins may have a beneficial role in COPD. The impact of statins on blood gene expression from COPD patients is largely unknown.

Objective

Identify blood gene signature associated with statin use in COPD patients, and the pathways underpinning this signature that could explain any potential benefits in COPD.

Methods

Whole blood gene expression was measured on 168 statin users and 451 non-users from the ECLIPSE study using the Affymetrix Human Gene 1.1 ST microarray chips. Factor Analysis for Robust Microarray Summarization (FARMS) was used to process the expression data. Differential

SUBMITTER: Obeidat M 

PROVIDER: S-EPMC4604084 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature