Exploring the effects of coexisting amyloid in subcortical vascular cognitive impairment.

ABSTRACT:

Background

Mixed pathology, particularly Alzheimer's disease with cerebrovascular lesions, is reported as the second most common cause of dementia. Research on mixed dementia typically includes people with a primary AD diagnosis and hence, little is known about the effects of co-existing amyloid pathology in people with vascular cognitive impairment (VCI). The purpose of this study was to understand whether individual differences in amyloid pathology might explain variations in cognitive impairment among individuals with clinical subcortical VCI (SVCI).

Methods

Twenty-two participants with SVCI completed an (11)C Pittsburgh compound B (PIB) position emission tomography (PET) scan to quantify global amyloid deposition. Cognitive function was measured using: 1) MOCA; 2) ADAS-C

SUBMITTER: Dao E 

PROVIDER: S-EPMC4604093 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature