Genetic Diversity of Plasmodium falciparum in Haiti: Insights from Microsatellite Markers.

ABSTRACT: Hispaniola, comprising Haiti and the Dominican Republic, has been identified as a candidate for malaria elimination. However, incomplete surveillance data in Haiti hamper efforts to assess the impact of ongoing malaria control interventions. Characteristics of the genetic diversity of Plasmodium falciparum populations can be used to assess parasite transmission, which is information vital to evaluating malaria elimination efforts. Here we characterize the genetic diversity of P. falciparum samples collected from patients at seven sites in Haiti using 12 microsatellite markers previously employed in population genetic analyses of global P. falciparum populations. We measured multiplicity of infections, level of genetic diversity, degree of population geographic substructure, and linkage dis

SUBMITTER: Carter TE 

PROVIDER: S-EPMC4604141 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature