Longitudinal regional brain volume loss in schizophrenia: Relationship to antipsychotic medication and change in social function.

ABSTRACT:

Background

Progressive brain volume loss in schizophrenia has been reported in previous studies but its cause and regional distribution remains unclear. We investigated progressive regional brain reductions in schizophrenia and correlations with potential mediators.

Method

Participants were drawn from the Northern Finland Birth Cohort 1966. A total of 33 schizophrenia individuals and 71 controls were MRI scanned at baseline (mean age=34.7, SD=0.77) and at follow-up (mean age=43.4, SD=0.44). Regional brain change differences and associations with clinical mediators were examined using FSL voxelwise SIENA.

Results

Schizophrenia cases exhibited greater progressive brain reductions than controls, mainly in the frontal and temporal lobes. The degree of periventricular brai

SUBMITTER: Guo JY 

PROVIDER: S-EPMC4604250 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature