Phylogenetic and genomic diversity in isolates from the globally distributed Acinetobacter baumannii ST25 lineage.

ABSTRACT: Acinetobacter baumannii is a globally distributed nosocomial pathogen that has gained interest due to its resistance to most currently used antimicrobials. Whole genome sequencing (WGS) and phylogenetics has begun to reveal the global genetic diversity of this pathogen. The evolution of A. baumannii has largely been defined by recombination, punctuated by the emergence and proliferation of defined clonal lineages. In this study we sequenced seven genomes from the sequence type (ST)25 lineage and compared them to 12 ST25 genomes deposited in public databases. A recombination analysis identified multiple genomic regions that are homoplasious in the ST25 phylogeny, indicating active or historical recombination. Genes associated with antimicrobial resistance were differentially distributed bet

SUBMITTER: Sahl JW 

PROVIDER: S-EPMC4604477 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature