How astrocyte networks may contribute to cerebral metabolite clearance.
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ABSTRACT:
SUBMITTER: Asgari M
PROVIDER: S-EPMC4604494 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Publications
How astrocyte networks may contribute to cerebral metabolite clearance.
Asgari Mahdi M de Zélicourt Diane D Kurtcuoglu Vartan V
Scientific reports 20151014
The brain possesses an intricate network of interconnected fluid pathways that are vital to the maintenance of its homeostasis. With diffusion being the main mode of solute transport in cerebral tissue, it is not clear how bulk flow through these pathways is involved in the removal of metabolites. In this computational study, we show that networks of astrocytes may contribute to the passage of solutes between tissue and paravascular spaces (PVS) by serving as low resistance pathways to bulk wate ...[more]
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