Genome-wide DNA methylome reveals the dysfunction of intronic microRNAs in major psychosis.

ABSTRACT:

Background

DNA methylation is thought to be extensively involved in the pathogenesis of many diseases, including major psychosis. However, most studies focus on DNA methylation alteration at promoters of protein-coding genes, despite the poor correlation between DNA methylation and gene expression.

Methods

We analyzed differentially methylated regions and differentially expressed genes in patients with schizophrenia and bipolar disorder and normal subjects. Gene expression and DNA methylation were analyzed with RNA-seq and MeDIP-seq of post-mortem brain tissue (brain region BA9) cohort in five schizophrenia, seven bipolar disorder cases and six controls, respectively.

Results

Here, we performed a large-scale integrative analysis using MeDIP-seq, coupled with RNA-seq,

SUBMITTER: Zhao H 

PROVIDER: S-EPMC4604612 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature