Multiplicative interaction of functional inflammasome genetic variants in determining the risk of gout.

ABSTRACT:

Introduction

The acute gout flare results from a localised self-limiting innate immune response to monosodium urate (MSU) crystals deposited in joints in hyperuricaemic individuals. Activation of the caspase recruitment domain-containing protein 8 (CARD8) NOD-like receptor pyrin-containing 3 (NLRP3) inflammasome by MSU crystals and production of mature interleukin-1β (IL-1β) is central to acute gouty arthritis. However very little is known about genetic control of the innate immune response involved in acute gouty arthritis. Therefore our aim was to test functional single nucleotide polymorphism (SNP) variants in the toll-like receptor (TLR)-inflammasome-IL-1β axis for association with gout.

Methods

1,494 gout cases of European and 863 gout cases of New Zealand (NZ) Polynesi

SUBMITTER: McKinney C 

PROVIDER: S-EPMC4604627 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature