The Role of Clinical Symptoms in the Diagnosis of Intrathoracic Tuberculosis in Young Children.

ABSTRACT:

Background

Childhood tuberculosis (TB) is usually Mycobacterium tuberculosis (MTB) culture negative. Furthermore, clinical presentation may be altered by active case finding, isoniazid prophylaxis and early treatment. We aimed to establish the value of presenting symptoms for intrathoracic TB case diagnosis among young children.

Methods

Healthy, HIV-uninfected, South African infants in an efficacy trial of a novel TB vaccine (MVA85A) were followed for 2 years for suspected TB. When suspected, investigation followed a standardized algorithm comprising symptom history, QuantiFERON Gold-in-Tube, chest radiography (CXR), MTB culture and Xpert MTB/RIF from paired gastric lavage and induced sputa. Adjusted odds ratios and 95% confidence intervals describe the associations between

SUBMITTER: Mulenga H 

PROVIDER: S-EPMC4604651 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature