Regulation of Clostridium difficile Spore Formation by the SpoIIQ and SpoIIIA Proteins.

ABSTRACT: Sporulation is an ancient developmental process that involves the formation of a highly resistant endospore within a larger mother cell. In the model organism Bacillus subtilis, sporulation-specific sigma factors activate compartment-specific transcriptional programs that drive spore morphogenesis. σG activity in the forespore depends on the formation of a secretion complex, known as the "feeding tube," that bridges the mother cell and forespore and maintains forespore integrity. Even though these channel components are conserved in all spore formers, recent studies in the major nosocomial pathogen Clostridium difficile suggested that these components are dispensable for σG activity. In this study, we investigated the requirements of the SpoIIQ and SpoIIIA proteins during C. difficile spor

SUBMITTER: Fimlaid KA 

PROVIDER: S-EPMC4605598 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature