Sparse Modeling Reveals miRNA Signatures for Diagnostics of Inflammatory Bowel Disease.

ABSTRACT: The diagnosis of inflammatory bowel disease (IBD) still remains a clinical challenge and the most accurate diagnostic procedure is a combination of clinical tests including invasive endoscopy. In this study we evaluated whether systematic miRNA expression profiling, in conjunction with machine learning techniques, is suitable as a non-invasive test for the major IBD phenotypes (Crohn's disease (CD) and ulcerative colitis (UC)). Based on microarray technology, expression levels of 863 miRNAs were determined for whole blood samples from 40 CD and 36 UC patients and compared to data from 38 healthy controls (HC). To further discriminate between disease-specific and general inflammation we included miRNA expression data from other inflammatory diseases (inflammation controls (IC): 24 chronic o

SUBMITTER: Hubenthal M 

PROVIDER: S-EPMC4605644 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature