Comparative Characterization of Cardiac Development Specific microRNAs: Fetal Regulators for Future.

ABSTRACT: MicroRNAs (miRNAs) are small, conserved RNAs known to regulate several biological processes by influencing gene expression in eukaryotes. The implication of miRNAs as another player of regulatory layers during heart development and diseases has recently been explored. However, there is no study which elucidates the profiling of miRNAs during development of heart till date. Very limited miRNAs have been reported to date in cardiac context. In addition, integration of large scale experimental data with computational and comparative approaches remains an unsolved challenge.The present study was designed to identify the microRNAs implicated in heart development using next generation sequencing, bioinformatics and experimental approaches. We sequenced six small RNA libraries prepared from diffe

SUBMITTER: Rustagi Y 

PROVIDER: S-EPMC4605649 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature