Transgene expression in the Nop-tTA driver line is not inherently restricted to the entorhinal cortex.

ABSTRACT: The entorhinal cortex (EC) plays a central role in episodic memory and is among the earliest sites of neurodegeneration and neurofibrillary tangle formation in Alzheimer's disease. Given its importance in memory and dementia, the ability to selectively modulate gene expression or neuronal function in the EC is of widespread interest. To this end, several recent studies have taken advantage of a transgenic line in which the tetracycline transactivator (tTA) was placed under control of the neuropsin (Nop) promoter to limit transgene expression within the medial EC and pre-/parasubiculum. Although the utility of this driver is contingent on its spatial specificity, no detailed neuroanatomical analysis of its expression has yet been conducted. We therefore undertook a systematic analysis of No

SUBMITTER: Yetman MJ 

PROVIDER: S-EPMC4605847 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature