Disuse rescues the age-impaired adaptive response to external loading in mice.

ABSTRACT:

Unlabelled

We aimed to determine whether aged bone's diminished response to mechanical loading could be rescued by modulating habitual activity. By reducing background loading, aged bone's response to loading increased to a level no different to young mice. This suggests, given the right stimulus, that ageing bone can respond to mechanical loading.

Introduction

Age-related decline in bone mass has been suggested to represent an impaired ability of bone to adapt to its mechanical environment. In young mice, the tibia's response to external mechanical loading has been shown to increase when habitual activity is reduced by sciatic neurectomy. Here we investigate if neurectomy can rescue bone's response to loading in old mice.

Methods

The effect of tibial disuse, induced

SUBMITTER: Meakin LB 

PROVIDER: S-EPMC4605986 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature