Immune cell interplay in colorectal cancer prognosis.

ABSTRACT: The immune response to colorectal cancer has proven to be a reliable measure of patient outcome in several studies. However, the complexity of the immune response in this disease is not well understood, particularly the interactions between tumour-associated cells and cells of the innate and adaptive immune system. This review will discuss the relationship between cancer associated fibroblasts and macrophages, as well as between macrophages and T cells, and demonstrate how each population may support or prevent tumour growth in a different immune environment.

SUBMITTER: Norton SE 

PROVIDER: S-EPMC4606176 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature