Association between COX-2 gene polymorphisms and risk of hepatocellular carcinoma development: a meta-analysis.

ABSTRACT:

Objective

To investigate the association between cyclo-oxygenase-2 (COX-2) polymorphism and the risk of hepatocellular carcinoma (HCC) development.

Design

Systematic review and meta-analysis of COX-2 polymorphism and risk of HCC development among people with or without HCC.

Data sources

EMBASE, PubMed, Public Library of Science, SCOPUS, Web of Knowledge and Chinese National Knowledge Infrastructure were searched for all clinical and experimental case-control studies of COX-2 polymorphism and HCC risk. Studies published up to March 2015 were included.

Review method

Ten studies were included for data extraction, which were mainly from Asian countries.

Results

2538 people with HCC and 3714 without HCC were found to satisfy the inclusion criteria and include

SUBMITTER: Lu SC 

PROVIDER: S-EPMC4606424 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature