Hypothermia and valproic acid activate prosurvival pathways after hemorrhage.

ABSTRACT:

Background

Therapeutic hypothermia (hypo) and valproic acid (VPA, a histone deacetylase inhibitor) have independently been shown to be protective in models of trauma and hemorrhagic shock but require logistically challenging doses to be effective. Theoretically, combined treatment may further enhance effectiveness, allowing us to use lower doses of each modality. The aim of this study was to determine whether a combination of mild hypo and VPA treatments would offer better cytoprotection compared with that of individual treatments in a hemorrhage model.

Materials and methods

Male Sprague-Dawley rats were subjected to 40% volume-controlled hemorrhage, kept in shock for 30 min, and assigned to one of the following treatment groups: normothermia (36°C-37°C), hypo (30 ± 2°C), no

SUBMITTER: Bambakidis T 

PROVIDER: S-EPMC4606462 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature