Intracellular calcium levels as screening tool for nanoparticle toxicity.

ABSTRACT: The use of engineered nano-sized materials led to revolutionary developments in many industrial applications and in the medical field. These materials, however, also may cause cytotoxicity. In addition to size, surface properties and shape were identified as relevant parameters for cell damage. Cell damage may occur as disruption of membrane integrity, induction of apoptosis and by organelle damage. Generation of oxidative stress may serve as an indicator for cytotoxicity. Effects occurring upon short contact of particles with cells, for instance in the systemic blood circulation, could be identified according to increases of intracellular [Ca(2+) ] levels, which are caused by variety of toxic stimuli. Negatively charged, neutral and positively charged polystyrene particles of different si

SUBMITTER: Meindl C 

PROVIDER: S-EPMC4606983 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature