Antitumor compounds from Streptomyces sp. KML-2, isolated from Khewra salt mines, Pakistan.

ABSTRACT:

Background

Actinomycetes are gram positive bacteria with high G + C content in their DNA and are capable of producing variety of secondary metabolites. Many of these metabolites possess different biological activities and have the potential to be developed as therapeutic agents. The aim of the present study was to screen actinomycetes inhabiting halophilic environment such as Khewra salt mines present in Pakistan for cytotoxic and antitumor compounds.

Results

An actiomycetes strain designated as Streptomyces sp. KML-2 was isolated from a saline soil of Khewra salt mines, Pakistan. The strain Streptomyces sp. KML-2 showed 84 % cytotoxic activity against larvae of Artemia salina. In the screening phase, the strain exhibited significant antitumor activity with IC50 values of 12

SUBMITTER: Aftab U 

PROVIDER: S-EPMC4607010 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature