Gene promoter polymorphism of RUNX2 and risk of osteoporosis in postmenopausal Indonesian women.

ABSTRACT:

Objectives

Osteoporosis is a metabolic bone disease of reduced bone mass density (BMD) and elevated risk of fracture due to an imbalance in bone formation and resorption. The risk and incidence of osteoporosis increase towards advanced age, particularly in postmenopausal women, and the risk is known to be affected by the variation in the expression of the associated regulatory genes. This work aimed to clarify the impact of variation in RUNX2 (runt domain transcription factor 2), which is an osteoblast-specific transcription factor that normally stimulates bone formation and osteoblast differentiation, regarding single-nucleotide polymorphism within RUNX2 promoter (P1) and risk of osteoporosis in postmenopausal Indonesian women.

Methods

Using DNA sampling from blood, the var

SUBMITTER: Auerkari EI 

PROVIDER: S-EPMC4607188 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature