Genome-wide analysis reveals the extent of EAV-HP integration in domestic chicken.

ABSTRACT: BACKGROUND:EAV-HP is an ancient retrovirus pre-dating Gallus speciation, which continues to circulate in modern chicken populations, and led to the emergence of avian leukosis virus subgroup J causing significant economic losses to the poultry industry. We mapped EAV-HP integration sites in Ethiopian village chickens, a Silkie, Taiwan Country chicken, red junglefowl Gallus gallus and several inbred experimental lines using whole-genome sequence data. RESULTS:An average of 75.22?±?9.52 integration sites per bird were identified, which collectively group into 279 intervals of which 5 % are common to 90 % of the genomes analysed and are suggestive of pre-domestication integration events. More than a third of intervals are specific to individual genomes, supporting active circulation of EAV-HP in modern chickens. Interval density is correlated with chromosome length (P?

SUBMITTER: Wragg D 

PROVIDER: S-EPMC4607243 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature