Differential Predictive Roles of A- and B-Type Nuclear Lamins in Prostate Cancer Progression.

ABSTRACT:

Background

Prostate cancer (PCa) is the most common cancer among men in western countries. While active surveillance is increasingly utilized, the majority of patients are currently treated with radical prostatectomy. In order to avoid over-treatment, there is an indisputable need for reliable biomarkers to identify the potentially aggressive and lethal cases. Nuclear intermediate filament proteins called lamins play a role in chromatin organization, gene expression and cell stiffness. The expression of lamin A is associated with poor outcome in colorectal cancer but to date the prognostic value of the lamins has not been tested in other solid tumors.

Methods

We studied the expression of different lamins with immunohistochemistry in a tissue microarray material of 501 PCa pa

SUBMITTER: Saarinen I 

PROVIDER: S-EPMC4607298 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature