Phenotypic clusters within sepsis-associated multiple organ dysfunction syndrome.

ABSTRACT:

Introduction

Sepsis is a devastating condition that is generally treated as a single disease. Identification of meaningfully distinct clusters may improve research, treatment and prognostication among septic patients. We therefore sought to identify clusters among patients with severe sepsis or septic shock.

Methods

We retrospectively studied all patients with severe sepsis or septic shock admitted directly from the emergency department to the intensive care units (ICUs) of three hospitals, 2006-2013. Using age and Sequential Organ Failure Assessment (SOFA) subscores, we defined clusters utilizing self-organizing maps, a method for representing multidimensional data in intuitive two-dimensional grids to facilitate cluster identification.

Results

We identified 2533 pat

SUBMITTER: Knox DB 

PROVIDER: S-EPMC4607311 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature