The Influence of Dietary Protein Intake on Mammalian Tryptophan and Phenolic Metabolites.

ABSTRACT: Although there has been increasing interest in the use of high protein diets, little is known about dietary protein related changes in the mammalian metabolome. We investigated the influence of protein intake on selected tryptophan and phenolic compounds, derived from both endogenous and colonic microbial metabolism. Furthermore, potential inter-species metabolic differences were studied. For this purpose, 29 healthy subjects were allocated to a high (n = 14) or low protein diet (n = 15) for 2 weeks. In addition, 20 wild-type FVB mice were randomized to a high protein or control diet for 21 days. Plasma and urine samples were analyzed with liquid chromatography-mass spectrometry for measurement of tryptophan and phenolic metabolites. In human subjects, we observed significant changes in pl

SUBMITTER: Poesen R 

PROVIDER: S-EPMC4607412 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature