Spatial and Working Memory Is Linked to Spine Density and Mushroom Spines.

ABSTRACT:

Background

Changes in synaptic structure and efficacy including dendritic spine number and morphology have been shown to underlie neuronal activity and size. Moreover, the shapes of individual dendritic spines were proposed to correlate with their capacity for structural change. Spine numbers and morphology were reported to parallel memory formation in the rat using a water maze but, so far, there is no information on spine counts or shape in the radial arm maze (RAM), a frequently used paradigm for the evaluation of complex memory formation in the rodent.

Methods

24 male Sprague-Dawley rats were divided into three groups, 8 were trained, 8 remained untrained in the RAM and 8 rats served as cage controls. Dendritic spine numbers and individual spine forms were counted in CA1

SUBMITTER: Mahmmoud RR 

PROVIDER: S-EPMC4607435 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature