Zinc transporter genes and urological cancers: integrated analysis suggests a role for ZIP11 in bladder cancer.

ABSTRACT: Although zinc transporters were shown to play roles in the development of prostate, bladder, and renal cancer, no study has evaluated the genetic variants in zinc transporter genes with risk of urological cancers. A candidate gene association study using genome-wide association study (GWAS) datasets was conducted for variants in 24 zinc transporter genes. Genotypes were analyzed using logistic regression models adjusted for covariates. The function of identified variants was assessed by using the Encyclopedia of DNA Elements (ENCODE). We further evaluated tumors for somatic change of the implicated gene(s) and the associations between identified variants and patient survival from data in The Cancer Genome Atlas (TCGA). A ZIP11 variant, rs8081059, was significantly associated with increased

SUBMITTER: Wu L 

PROVIDER: S-EPMC4607554 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature