In Vivo Multiphoton Microscopy of Basal Cell Carcinoma.

ABSTRACT:

Importance

Basal cell carcinomas (BCCs) are diagnosed by clinical evaluation, which can include dermoscopic evaluation, biopsy, and histopathologic examination. Recent translation of multiphoton microscopy (MPM) to clinical practice raises the possibility of noninvasive, label-free in vivo imaging of BCCs that could reduce the time from consultation to treatment.

Objectives

To demonstrate the capability of MPM to image in vivo BCC lesions in human skin, and to evaluate if histopathologic criteria can be identified in MPM images.

Design, setting, and participants

Imaging in patients with BCC was performed at the University of California-Irvine Health Beckman Laser Institute & Medical Clinic, Irvine, between September 2012 and April 2014, with a clinical MPM-based tomog

SUBMITTER: Balu M 

PROVIDER: S-EPMC4607557 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature