Differential distribution of GABA and glycine terminals in the inferior colliculus of rat and mouse.

ABSTRACT: The inferior colliculus (IC), the midbrain component of the auditory pathway, integrates virtually all inputs from the auditory brainstem. These are a mixture of excitatory and inhibitory ascending inputs, and the inhibitory transmitters include both gamma-aminobutyric acid (GABA) and glycine (GLY). Although the presence of these inhibitory inputs is well established, their relative location in the IC is not, and there is little information on the mouse. Here, we study the distribution of glutamic acid decarboxylase (GAD)67 and GLY transporter 2 (T2) in axonal terminals to better understand the relative contributions of these inputs. Large-scale mosaic composite images of immunohistochemistry sections of rat and mice were used to isolate the signals related to the concentrations of these a

SUBMITTER: Choy Buentello D 

PROVIDER: S-EPMC4607567 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature