Interictal, circulating sphingolipids in women with episodic migraine: A case-control study.

ABSTRACT:

Objective

To evaluate interictal, circulating sphingolipids in women migraineurs.

Methods

In the fasting state, serum samples were obtained pain-free from 88 women with episodic migraine (EM; n=52) and from controls (n=36). Sphingolipids were detected and quantified by high-performance liquid chromatography coupled with tandem mass spectrometry using multiple reaction monitoring. Multivariate logistic regression was used to examine the association between serum sphingolipids and EM odds. A recursive partitioning decision tree based on the serum concentrations of 10 sphingolipids was used to determine the presence or absence of EM in a subset of participants.

Results

Total ceramide (EM 6,502.9 ng/mL vs controls 10,518.5 ng/mL; p<0.0001) and dihydroceramide (EM 39.3 ng/

SUBMITTER: Peterlin BL 

PROVIDER: S-EPMC4607595 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature