The 2D:4D ratio, a proxy for prenatal androgen levels, differs in men with and without MS.

ABSTRACT:

Objective

To determine whether the 2D:4D ratio (ratio of the second and fourth digit lengths), a proxy for lower prenatal androgen to estrogen ratio, differs in men with and without multiple sclerosis (MS) using a case-control study design.

Methods

We obtained 2 digital scans of the right hand for men with MS presenting to a scheduled clinic visit at a large MS referral center, and for men without autoimmune or endocrine diseases. All individuals were aged 18 to 65 years, right-handed, and reported no prior digit trauma. We calculated a mean 2D:4D ratio using digital calipers. In participants with MS, we assessed age at first MS symptoms, MS type, and the MS Severity Score; 51 had provided a testosterone level within 10 years of symptom onset. Our primary analysis was a cros

SUBMITTER: Bove R 

PROVIDER: S-EPMC4607599 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature