Maternal occupational pesticide exposure and risk of congenital heart defects in the National Birth Defects Prevention Study.

ABSTRACT:

Background

Congenital heart defects (CHDs) are common birth defects, affecting approximately 1% of live births. Pesticide exposure has been suggested as an etiologic factor for CHDs, but previous results were inconsistent.

Methods

We examined maternal occupational exposure to fungicides, insecticides, and herbicides for 3328 infants with CHDs and 2988 unaffected control infants of employed mothers using data for 1997 through 2002 births from the National Birth Defects Prevention Study, a population-based multisite case-control study. Potential pesticide exposure from 1 month before conception through the first trimester of pregnancy was assigned by an expert-guided task-exposure matrix and job history details self-reported by mothers. Odds ratios (ORs) and 95% confidence int

SUBMITTER: Rocheleau CM 

PROVIDER: S-EPMC4607631 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature