Metaproteomics reveals functional shifts in microbial and human proteins during a preterm infant gut colonization case.

ABSTRACT: Microbial colonization of the human gastrointestinal tract plays an important role in establishing health and homeostasis. However, the time-dependent functional signatures of microbial and human proteins during early colonization of the gut have yet to be determined. To this end, we employed shotgun proteomics to simultaneously monitor microbial and human proteins in fecal samples from a preterm infant during the first month of life. Microbial community complexity increased over time, with compositional changes that were consistent with previous metagenomic and rRNA gene data. More specifically, the function of the microbial community initially involved biomass growth, protein production, and lipid metabolism, and then switched to more complex metabolic functions, such as carbohydrate met

SUBMITTER: Young JC 

PROVIDER: S-EPMC4607655 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature