Total Synthesis of Lignan Lactone (-)-Hinokinin.

ABSTRACT: This research paper is aimed at studying the total synthesis of pharmacologically active lignan (-)-hinokinin. The synthesis features a three-step cascade reaction involving highly stereoselective Michael addition, anion-oxidative hydroxylation, and oxygen anion cyclization to construct the pivotal butyrolactonimidate intermediate.

SUBMITTER: Zhou QL 

PROVIDER: S-EPMC4607678 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature