HIV Infection Is Associated With Progression of Subclinical Carotid Atherosclerosis.

ABSTRACT:

Background

Individuals infected with human immunodeficiency virus (HIV) live longer as a result of effective treatment, but long-term consequences of infection, treatment, and immunological dysfunction are poorly understood.

Methods

We prospectively examined 1011 women (74% HIV-infected) in the Women's Interagency HIV Study and 811 men (65% HIV-infected) in the Multicenter AIDS Cohort Study who underwent repeated B-mode carotid artery ultrasound imaging in 2004-2013. Outcomes included changes in right common carotid artery intima-media thickness (CCA-IMT) and new focal carotid artery plaque formation (IMT >1.5 mm) over median 7 years. We assessed the association between HIV serostatus and progression of subclinical atherosclerosis, adjusting for demographic, behavioral, and

SUBMITTER: Hanna DB 

PROVIDER: S-EPMC4607734 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature