Linking Exposures of Particles Released From Nano-Enabled Products to Toxicology: An Integrated Methodology for Particle Sampling, Extraction, Dispersion, and Dosing.

ABSTRACT: Nano-enabled products (NEPs) represent a growing economic global market that integrates nanotechnology into our everyday lives. Increased consumer use and disposal of NEPs at their end of life has led to increased environmental, health and safety (EHS) concerns, due to the potential environmental release of constituent engineered nanomaterials (ENMs) used in the production of NEPs. Although, there is an urgent need to assess particulate matter (PM) release scenarios and potential EHS implications, no current standardized methodologies exist across the exposure-toxicological characterization continuum. Here, an integrated methodology is presented, that can be used to sample, extract, disperse and estimate relevant dose of life cycle-released PM (LCPM), for in vitro and in vivo toxicological

SUBMITTER: Pal AK 

PROVIDER: S-EPMC4607749 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature