Why You Really Should Consider Using Palladium-Catalyzed Cross-Coupling of Silanols and Silanolates.

ABSTRACT: The transition metal-catalyzed cross-coupling of organometallic nucleophiles derived from tin, boron, and zinc with organic electrophiles enjoys a preeminent status among modern synthetic methods for the formation of carbon-carbon bonds. In recent years, organosilanes have emerged as viable alternatives to the conventional reagents, with the added benefits of low cost, low toxicity and high chemical stability. However, silicon-based cross-coupling reactions often require heating in the presence of a fluoride source, which has significantly hampered their widespread acceptance. To address the "fluoride problem", a new paradigm for palladium-catalyzed, silicon-based cross-coupling reactions has been developed that employs a heretofore underutilized class of silicon reagents, the organosil

SUBMITTER: Denmark SE 

PROVIDER: S-EPMC4608042 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature