Bioelectric memory: modeling resting potential bistability in amphibian embryos and mammalian cells.

ABSTRACT:

Background

Bioelectric gradients among all cells, not just within excitable nerve and muscle, play instructive roles in developmental and regenerative pattern formation. Plasma membrane resting potential gradients regulate cell behaviors by regulating downstream transcriptional and epigenetic events. Unlike neurons, which fire rapidly and typically return to the same polarized state, developmental bioelectric signaling involves many cell types stably maintaining various levels of resting potential during morphogenetic events. It is important to begin to quantitatively model the stability of bioelectric states in cells, to understand computation and pattern maintenance during regeneration and remodeling.

Method

To facilitate the analysis of endogenous bioelectric signaling an

SUBMITTER: Law R 

PROVIDER: S-EPMC4608135 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature