Reversible activation of pH-sensitive cell penetrating peptides attached to gold surfaces.

ABSTRACT: pH-sensitive viral fusion protein mimics are widely touted as a promising route towards site-specific delivery of therapeutic compounds across lipid membranes. Here, we demonstrate that a fusion protein mimic, designed to achieve a reversible, pH-driven helix-coil transition mechanism, retains its functionality when covalently bound to a surface.

SUBMITTER: Baio JE 

PROVIDER: S-EPMC4608256 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature