Variable exon usage of differentially-expressed genes associated with resistance of sheep to Teladorsagia circumcincta.

ABSTRACT: The resistance and susceptibility of sheep to the common abomasal nematode parasite, Teladorsagia circumcincta is strongly associated with the differential polarization of the immune response. Resistant animals control larval colonization by the production of a protective antibody response regulated by Th2 T cells. Susceptible sheep respond to infection by developing an inflammatory Th1/Th17 response that fails to control infection. Previous microarray analysis identified genes associated with T cell polarization that were differentially expressed between the resistant and susceptible sheep. RT-qPCR confirmed the microarray data for ALOX15 and IL13. Both ALOX15 exon 9 and IL13 exon 4 were significantly increased in resistant animals and copy number RT-qPCR showed that expression levels of

SUBMITTER: Wilkie H 

PROVIDER: S-EPMC4608359 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature