NeuroTransDB: highly curated and structured transcriptomic metadata for neurodegenerative diseases.

ABSTRACT: Neurodegenerative diseases are chronic debilitating conditions, characterized by progressive loss of neurons that represent a significant health care burden as the global elderly population continues to grow. Over the past decade, high-throughput technologies such as the Affymetrix GeneChip microarrays have provided new perspectives into the pathomechanisms underlying neurodegeneration. Public transcriptomic data repositories, namely Gene Expression Omnibus and curated ArrayExpress, enable researchers to conduct integrative meta-analysis; increasing the power to detect differentially regulated genes in disease and explore patterns of gene dysregulation across biologically related studies. The reliability of retrospective, large-scale integrative analyses depends on an appropriate combinati

SUBMITTER: Bagewadi S 

PROVIDER: S-EPMC4608514 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature