Association of Somatic Mutations of ADAMTS Genes With Chemotherapy Sensitivity and Survival in High-Grade Serous Ovarian Carcinoma.

ABSTRACT:

Importance

Chemotherapy response in the majority of patients with ovarian cancer remains unpredictable.

Objective

To identify novel molecular markers for predicting chemotherapy response in patients with ovarian cancer.

Design, setting, and participants

Observational study of genomics and clinical data of high-grade serous ovarian cancer cases with genomic and clinical data made public between 2009 and 2014 via the Cancer Genome Atlas project.

Main outcomes and measures

Chemotherapy response (primary outcome) and overall survival (OS), progression-free survival (PFS), and platinum-free duration (secondary outcome).

Results

In 512 patients with ovarian cancer with available whole-exome sequencing data, mutations from 8 members of the ADAMTS family (ADAMTS

SUBMITTER: Liu Y 

PROVIDER: S-EPMC4608536 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature