X-ray structures of Drosophila dopamine transporter in complex with nisoxetine and reboxetine.

ABSTRACT: Most antidepressants elicit their therapeutic benefits through selective blockade of Na(+)/Cl(-)-coupled neurotransmitter transporters. Here we report X-ray structures of the Drosophila melanogaster dopamine transporter in complexes with the polycyclic antidepressants nisoxetine or reboxetine. The inhibitors stabilize the transporter in an outward-open conformation by occupying the substrate-binding site. These structures explain how interactions between the binding pocket and substituents on the aromatic rings of antidepressants modulate drug-transporter selectivity.

SUBMITTER: Penmatsa A 

PROVIDER: S-EPMC4608549 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature